A detrimental mitochondrial-nuclear interaction causes cytoplasmic male sterility in rice

Luo, D. and Xu, H. and Liu, Z. and et al, . (2013) A detrimental mitochondrial-nuclear interaction causes cytoplasmic male sterility in rice. Nature Genetics. pp. 1-7.

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Plant cytoplasmic male sterility (CMS) results from incompatibilities between the organellar and nuclear genomes and prevents self pollination, enabling hybrid crop breeding to increase yields1–6. The Wild Abortive CMS (CMS-WA) has been exploited in the majority of ‘three-line’ hybrid rice production since the 1 1970s, but the molecular basis of this trait remains unknown. Here we report that a new mitochondrial gene, WA352, which originated recently in wild rice, confers CMS-WA because the protein it encodes interacts with the nuclear-encoded mitochondrial protein COX1111. In CMS-WA lines, WA352 accumulates preferentially in the anther tapetum, thereby inhibiting COX11 11 11 function in peroxide metabolism and triggering premature tapetal programmed cell death and consequent pollen abortion. WA352-induced sterility can be suppressed by two restorer-of-fertility (Rf) genes, suggesting the existence of different mechanisms to counteract deleterious cytoplasmic factors. Thus, CMS-related cytoplasmic-nuclear incompatibility is driven by a detrimental interaction between a newly evolved mitochondrial gene and a conserved, essential nuclear gene.

Item Type: Article
Author Affiliation: 1State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Key Laboratory of Plant Functional Genomics and Biotechnology of Guangdong Provincial Higher Education Institutions, College of Life Sciences, South China Agricultural University, Guangzhou, China.
Subjects: Crop Improvement > Genetics/Genomics
Divisions: Other Crops
Depositing User: Mr Siva Shankar
Date Deposited: 03 Apr 2013 10:20
Last Modified: 03 Apr 2013 10:20
Official URL: http://dx.doi.org/10.1038/ng.2570
URI: http://eprints.icrisat.ac.in/id/eprint/10189

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