Potential of Aspergillus flavus genomics for applications in biotechnology

Cleveland , T.E. and Yu , J. and Fedorova , N. and et al, . (2009) Potential of Aspergillus flavus genomics for applications in biotechnology. Trends in Biotechnology, 27 (3). pp. 151-157.

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Aspergillus flavus is a common saprophyte and opportunistic pathogen that produces numerous secondary metabolites. The primary objectives of the A. flavus genomics program are to reduce and eliminate aflatoxin contamination in food and feed and to discover genetic factors that contribute to plant and animal pathogenicity. A. flavus expressed sequence tags (ESTs) and whole-genome sequencing have been completed. Annotation of the A. flavus genome has revealed numerous genes and gene clusters that are potentially involved in the formation of aflatoxin and other secondary metabolites, as well as in the degradation of complex carbohydrate polymers. Analysis of putative secondary metabolism pathways might facilitate the discovery of new compounds with pharmaceutical properties, as well as new enzymes for biomass degradation.

Item Type: Article
Uncontrolled Keywords: Aspergillus flavus, Genomics, Biotechnology
Author Affiliation: United States Department of Agriculture, Agricultural Research Service (USDA/ARS), Southern Regional Research Center, USA.
Subjects: Crop Improvement
Divisions: General
Depositing User: Mr Arbind Seth
Date Deposited: 09 May 2013 05:05
Last Modified: 09 May 2013 05:05
Official URL: http://dx.doi.org/10.1016/j.tibtech.2008.11.008
URI: http://eprints.icrisat.ac.in/id/eprint/10492

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