Emerging roles for centromeres in meiosis I chromosome segregation

Brar , G.A. and Amon, A. (2008) Emerging roles for centromeres in meiosis I chromosome segregation. Nature Reviews Genetics, 9 (12). pp. 899-910.

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Centromeres are an essential and conserved feature of eukaryotic chromosomes, yet recent research indicates that we are just beginning to understand the numerous roles that centromeres have in chromosome segregation. During meiosis I, in particular, centromeres seem to function in many processes in addition to their canonical role in assembling kinetochores, the sites of microtubule attachment. Here we summarize recent advances that place centromeres at the centre of meiosis I, and discuss how these studies affect a variety of basic research fields and thus hold promise for increasing our understanding of human reproductive defects and disease states

Item Type: Article
Uncontrolled Keywords: Centromeres, Disease, Chromatin, Meiosis, Protein, Nematodes
Author Affiliation: David H. Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, 40 Ames Street, Cambridge, Massachusetts 02139, USA
Subjects: Crop Improvement > Genetics/Genomics
Divisions: General
Depositing User: Ms Ishrath Durafsha
Date Deposited: 25 Jun 2014 03:52
Last Modified: 25 Jun 2014 03:52
Official URL: http://dx.doi.org/10.1038/nrg2454
URI: http://eprints.icrisat.ac.in/id/eprint/13267

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