Gene–environment-wide association studies: emerging approaches

Thomas, D. (2010) Gene–environment-wide association studies: emerging approaches. Nature Reviews Genetics, 11. pp. 259-272.

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Despite the yield of recent genome-wide association (GWA) studies, the identified variants explain only a small proportion of the heritability of most complex diseases. This unexplained heritability could be partly due to gene–environment (G×E) interactions or more complex pathways involving multiple genes and exposures. This Review provides a tutorial on the available epidemiological designs and statistical analysis approaches for studying specific G×E interactions and choosing the most appropriate methods. I discuss the approaches that are being developed for studying entire pathways and available techniques for mining interactions in GWA data. I also explore methods for marrying hypothesis-driven pathway-based approaches with ‘agnostic’ GWA studies

Item Type: Article
Author Affiliation: Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, CHP‑220, Los Angeles, California 90089‑9011, USA
Subjects: Crop Improvement > Genetics/Genomics
Divisions: Other Crops
Depositing User: Ms K Syamalamba
Date Deposited: 27 Aug 2014 05:01
Last Modified: 27 Aug 2014 05:01
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