Goitrogenic effects of pearl millet diets

Klopfenstein, C.F. and Hoseney, R.C. and Leipold, H.W. (1983) Goitrogenic effects of pearl millet diets. Nutrition Reports International, 27 (5). pp. 1039-1047.

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For 6 weeks male Wistar rats weighing 147 g were given a diet of pearl millet, fermented millet, grain sorghum, millet bran 15 and sorghum endosperm 85% or sorghum bran 15 and millet endosperm 85%. All diets were adequate in iodine. Rats given millet or fermented millet showed histological changes in their thyroid similar to those which occur in human colloidal goitre. Thyroxine (T4) was greater and triiodothyronine (T3) less in rats given millet than in those given sorghum. The results suggest that the "goitrogen" might act by inhibiting the conversion of T4 to T3, the most active form of the hormone. Millet's goitrogenic agent is apparently associated with the bran and endosperm fractions and might be related to the grain's high content of minerals.ADDITIONAL ABSTRACT:This paper includes a table of the mineral contents of (i) pearl millet and (ii) grain sorghum: (i) contains (p.p.m.) 59 Na, 4260 K, 384 Ca, 2900 P, 4.18 Cu, 10.5 Zn, 76.7 Fe; and (ii) contains correspondingly 61, 2800, 382, 2100, 0.48, 3.80 and 23.9.

Item Type: Article
Author Affiliation: Department Grain Science and Industry, Kansas State University Manhattan
Subjects: Postharvest Management
Divisions: Millet
Depositing User: Mr. SanatKumar Behera
Date Deposited: 18 May 2012 05:10
Last Modified: 18 May 2012 05:10
URI: http://eprints.icrisat.ac.in/id/eprint/5458

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