Platelet Aggregation and Anti-Inflammatory Effects of Garden Pea, Desi Chickpea and Kabuli Chickpea

Zia-Ul-Haq, M. and Khanday, B.A. and Landa, P. and Kutil, Z. and Ahmed, S. and Qayum, M. and Ahmed, M (2012) Platelet Aggregation and Anti-Inflammatory Effects of Garden Pea, Desi Chickpea and Kabuli Chickpea. Acta Poloniae Pharmaceutica ñ Drug Research, 69 (4). pp. 707-711.

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Inflammation is the natural body defense mechanism for the removal of injurious agents, necrosed cells and tissues from the body. This study was aimed to evaluate the anti-inflammatory and platelet aggregation effects of three medicinal plants of Pakistan. Methanolic extract of Garden pea inhibited arachidonic acid (AA)-induced platelet aggregation (IC50 = 35 μg/mL) and platelet activating factor (PAF)-induced platelet aggregation (IC50 = 38 μg/mL) in a dose dependent fashion. Methanolic extract of Desi chickpea inhibited arachidonic acid (AA) induced platelet aggregation (IC50 value = AA = 46 μg/mL) in dose dependent fashion while was found not active against PAF-induced platelet aggregation. Methanolic extract of Kabuli chickpea was found not active against both arachidonic acid (AA)-induced platelet aggregation and PAF-induced platelet aggregation. The best potential to inhibit in vitro COX-2 activity showed garden pea (Pisum sativum; the synthesis of PGE2 reduced by 92% in comparison with untreated control wells) followed by Desi chickpea (Cicer arietinum var; 87% inhibition) and Kabuli chickpea extracts (Cicer arietinum var; 65% inhibition). All extracts were tested at concentration 20 μg/mL. in COX-2 assay.The results indicate that if the same were happening in vivo, Garden pea, Desi chickpea and Kabuli chickpea could be useful as natural antithrombotic anti-inflammatory materials.

Item Type: Article
Author Affiliation: University of Karachi, Karachi, Gomal University, University of Bahawalpur.....
Subjects: Plant Production
Plant Protection
Divisions: Chickpea
Depositing User: Mr. SanatKumar Behera
Date Deposited: 03 Jul 2012 06:42
Last Modified: 03 Jul 2012 06:42

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