Bioactive N-isobutylamides from the flower buds of Spilanthes acmella

Ramsewak, R. S. and Erickson, A. J. and Nair, M. G. (1999) Bioactive N-isobutylamides from the flower buds of Spilanthes acmella. Phytochemistry, 51 (6). pp. 729-732.

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The hexane extract of dried flower buds of Spilanthes acmella afforded three N-isobutyl amides: spilanthol, undeca-2E,7Z,9E- trienoic acid isobutylamide and undeca-2E-en-8,10-diynoic acid isobutylamide. Their structures were determined by 1H and 13C NMR, MS and GC±MS spectroscopic methods. All were active against Aedes aegyptii larvae and Helicoverpa zea neonates at 12.5 and 250 mg/mL concentrations, respectively.

Item Type: Article
Additional Information: This is a contribution from the Michigan State University Agricultural Experiment Station. A. aegyptii eggs were supplied by Dr. A. Raikhel and Dr. A. Hays, Department of Botany and Plant Pathology, Michigan State University. The NMR data were obtained on instrumentation that was purchased in part with the funds from NIH grant # 1-S10- RR04750, NSF grant # CHE-88-00770 and NSF grant # CHE-92-13241.
Uncontrolled Keywords: Spilanthes acmella, Compositae, Heliantheae, N-isobutyl amides, Acetylenic compounds, Spilanthol
Author Affiliation: Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
Subjects: Crop Improvement
Divisions: Other Crops
Depositing User: Mr Siva Shankar
Date Deposited: 16 Aug 2012 05:20
Last Modified: 16 Aug 2012 05:22
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