Milk phospholipid and plant sterol-dependent modulation of plasma lipids in healthy volunteers

Keller, S. and Malarski, A. and Reuther, C. and Kertscher, R. and Kiehntopf, M. and Jahreis, G. (2012) Milk phospholipid and plant sterol-dependent modulation of plasma lipids in healthy volunteers. European Journal of Nutrition. pp. 1-11.

[img] PDF (Online First) - Published Version
Restricted to ICRISAT researchers only

Request a copy


Purpose Hypolipidemic and/or hypocholesterolemic effects are presumed for dietary milk phospholipid (PL) as well as plant sterol (PSt) supplementation. The aim was to induce changes in plasma lipid profile by giving different doses of milk PL and a combination of milk PL with PSt to healthy volunteers. Methods In an open-label intervention study, 14 women received dairy products enriched with moderate (3 g PL/ day) or high (6 g PL/day) dose of milk PL or a high dose of milk PL combined with PSt (6 g PL/day ? 2 g PSt/day) during 3 periods each lasting 10 days. Results Total cholesterol concentration and HDL cho-lesterol concentration were reduced following supplemen-tation with 3 g PL/day. No significant change in LDL cholesterol concentration was found compared with base-line. High PL dose resulted in an increase of LDL cho-lesterol and unchanged HDL cholesterol compared with moderate PL dose. The LDL/HDL ratio and triglyceride concentration remained constant within the study. Except for increased phosphatidyl ethanolamine concentrations, plasma PL concentrations were not altered during exclu-sive PL supplementations. A combined high-dose PL and PSt supplementation led to decreased plasma LDL cho-lesterol concentration, decreased PL excretion, increased plasma sphingomyelin/phosphatidyl choline ratio, and significant changes in plasma fatty acid distribution com-pared with exclusive high-dose PL supplementation. Conclusion Milk PL supplementations influence plasma cholesterol concentrations, but without changes of LDL/HDL ratio. A combined high-dose milk PL and PSt supplementation decreases plasma LDL cholesterol concentration, but it prob-ably enforces absorption of fatty acids or fatty acid-containing hydrolysis products that originated during lipid digestion.

Item Type: Article
Additional Information: We would like to thank our volunteers for their engaged participation in the study. Nasim Kroegel is acknowledged for language editing. This research project was supported by the German Ministry of Economics and Technology (via AiF) and the FEI (Forschungskreis der Erna¨hrungsindustrie e.V., Bonn). Project AiF 316ZBG.
Uncontrolled Keywords: Sphingomyelin, Phosphatidyl choline,� Cholesterol, Bile acids, Fatty acids, Dairy products
Author Affiliation: Friedrich Schiller University Jena,Germany
Subjects: Postharvest Management
Crop Improvement
Plant Physiology and Biochemistry > Plant Physiology
Divisions: General
Depositing User: Mr Arbind Seth
Date Deposited: 01 Oct 2012 06:17
Last Modified: 01 Oct 2012 06:17
Official URL:

Actions (login required)

View Item View Item