Rationalizing investment and effort in whole genome sequencing for harvesting applied benefits

Bhat, S.R. (2011) Rationalizing investment and effort in whole genome sequencing for harvesting applied benefits. Current Science , 100 (11). pp. 1633-1637.

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Whole genome sequencing of higher organisms was considered a major challenge about two decades ago. Thanks to the rapid developments in sequencing technologies, genome sequencing has now become faster, cheaper and technically less demanding. India participated in international genome sequencing projects of rice and tomato, and has independently initiated work on whole genome sequencing of Mesorhizobium ciceri and buffalo. With whole genome sequence data of more than 1500 organisms already available in public databases, and more added on a weekly basis, the excitement is waning. Considering that structural genomics is only the starting point for a detailed analysis of function, the investment in whole genome sequencing needs to be balanced with its intended downstream applications. In this article, we discuss the relevance of whole genome sequencing for agricultural applications and emphasize the need for urgent investment in development of appropriate tools, biological resources and human capacity in biotechnology and bioinformatics to reap full benefits.

Item Type: Article
Additional Information: I thank Prof. V. L. Chopra and Dr R. Srinivasan, National Research Centre on Plant Biotechnology, New Delhi for suggestions and comments on the manuscript.
Uncontrolled Keywords: Microarray, Molecular markers, Transgenics, Whole genome sequencing.
Author Affiliation: National Research Centre on Plant Biotechnology, India.
Subjects: Crop Improvement
Crop Improvement > Genetics/Genomics
Divisions: General
Depositing User: Mr Arbind Seth
Date Deposited: 01 Jan 2013 09:22
Last Modified: 01 Jan 2013 09:22
Official URL: http://www.currentscience.ac.in/Volumes/100/11/163...
URI: http://eprints.icrisat.ac.in/id/eprint/9141

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