Synthetic Chromosome Platforms in Plants

Gaeta, R.T. and Masonbrink, R.E and Krishnaswamy, L. and et al, . (2012) Synthetic Chromosome Platforms in Plants. Annual Review of Plant Biology, 63. pp. 307-330.

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Synthetic chromosomes provide themeans to stack transgenes independently of the remainder of the genome. Combining them with haploid breeding could provide the means to transfer many transgenes more easily among varieties of the same species. The epigenetic nature of centromere formation complicates the production of synthetic chromosomes. However, telomere-mediated truncation coupled with the introduction of site-specific recombination cassettes has been used to produce minichromosomes consisting of littlemore than a centromere. Methods that have been developed to modify genes in vivo could be applied to minichromosomes to improve their utility and to continue to increase their length and genic content. Synthetic chromosomes establish the means to add or subtract multiple transgenes, multigene complexes, or whole biochemical pathways to plants to change their properties for agricultural applications or to use plants as factories for the production of foreign proteins or metabolites.

Item Type: Article
Additional Information: Research on this topic was supported by National Science Foundation grant DBI 0701297.
Uncontrolled Keywords: centromere, telomere, artificial chromosomes, engineered minichromosomes, transgenes, biotechnology
Author Affiliation: Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211
Subjects: Crop Improvement > Genetics/Genomics
Crop Improvement > Biotechnology
Divisions: General
Depositing User: Mr Balakrishna Garadasu
Date Deposited: 26 Feb 2013 03:40
Last Modified: 26 Feb 2013 03:40
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